You could generate an executable with a pruned image. At least with the commercial Smalltalks.
For example, this is how VisualWorks Smalltalk does it (Application Delivery chapter):
www.cincomsmalltalk.com/main/Documentation/VisualWorks/AppDevGuide.pdf
It also comes with Seaside, which is a pretty nice web app framework, and will run out of the box. Instructions here:
http://smalltalk.gnu.org/blog/bonzinip/seaside-development-g...