Clojure macros are the antithesis of simple, and the need to indent a scope for every new variable actually fights against TDD in my experience.
I recently wrote a good chunk of a RESTful SQL-backed application in Python in two days that took a team of 3 people in Clojure over 2 months to just get to the basic level of library support one would expect from things like sqlalchemy and flask.
Clojure isn't simple -- it's basically a step up from assembler in how little it provides.
Simplicity is having all the power tools and being able to put them together and be instantly productive, and to support programming in multiple paradigms.
While it's not the norm, I sometimes feel many FP purists spend so much time debating purity and giving basic concepts complex names - when they could be using something else and getting much more done.
Side effects aren't the devil and are sometimes neccessary to get real work done. Bad code can be written in anything, and it just takes experience.
I'd much rather see a language focus on readability, maintaince, and rapid prototyping than side effects.
Functional programming concepts have benefits - I love list comprehensions and functools.partial in python is pretty neat, but when you can also have a decent object system, and embrace imperative when steps are truly imperative, you can get a whole lot more done.