http://snpedia.com/index.php/Rs1421085
has a wider collection of the literature and links to the recently published http://www.ncbi.nlm.nih.gov/pubmed/26287746 which finally establishes this as the causative snp and explains the method of action.
has a wider collection of the literature and links to the recently published http://www.ncbi.nlm.nih.gov/pubmed/26287746 which finally establishes this as the causative snp and explains the method of action.
http://onlinelibrary.wiley.com/doi/10.1038/oby.2008.318/abst...
Which is a much simpler explanation.
And even so, carriers of even the highest risk form of the gene are still on average only 6.6lbs heavier than normal: