The smallpox vaccine is a strong contender. Smallpox killed 300m people in the 20th century, more than all wars combined. And we wiped it out.
" In the late 1940s and early 1950s, Leslie Collier, an English microbiologist working at the Lister Institute of Preventive Medicine, developed a method for producing a heat-stable freeze-dried vaccine in powdered form.[50][51] Collier added 0.5% phenol to the vaccine to reduce the number of bacterial contaminants but the key stage was to add 5% peptone to the liquid vaccine before it was dispensed into ampoules. This protected the virus during the freeze drying process. After drying the ampoules were sealed under nitrogen. Like other vaccines, once reconstituted it became ineffective after 1–2 days at ambient temperatures. However, the dried vaccine was 100% effective when reconstituted after 6 months storage at 37 °C (99 °F) allowing it to be transported to, and stored in, remote tropical areas. Collier's method was increasingly used and, with minor modifications, became the standard for vaccine production adopted by the WHO Smallpox Eradication Unit when it initiated its global Smallpox Eradication Campaign in 1967 " -- https://en.wikipedia.org/wiki/Smallpox_vaccine
That speaker was right: don't underestimate the impact of bicycles.
It's easy to say that in hindsight, but given all of the tension around the Iron Curtain and all of the times the US and USSR came very close indeed to going to war despite how likely total nuclear destruction was, it seems short-sighted to just brush off the idea of that war actually happening if neither side had any nuclear weapons.
History isn't over yet. The risk is probably higher now than at any time since it peaked in the mid-80s.
Ultimately, one naval officer's minority vote[1] prevented a Soviet sub from launching a tactical nuclear weapon at US shipping. Several thousand miles of ocean prevented the Soviet Union from feasibly achieving decisive military victory against the United States. [1]https://en.wikipedia.org/wiki/Vasili_Arkhipov
For their part, the Soviets were very worried about a combined NATO invasion, which seems quite reasonable considering that Germany alone, while also fighting/occupying most of the rest of Europe, managed to get to the suburbs of Moscow, and kill millions of Russians along the way.
Now if the Soviets did manage to invade and conquer Western Europe and maintain control over it, then they might be in a rather better position to consider direct attacks against the US. Which is a good part of the reason why the US invested so much in keeping them out of Western Europe.
It didn't prevent the superpowers from having wars with each other. It just shifted the battle fronts, so now the superpowers fight through proxy wars, and the deaths all happen in distant, "developing" countries.
By that logic, we can 'never know' anything about historical effects, ever, and it's pointless to discuss the consequences of any historical events, including the others you mentioned. But really, the effect of the nuclear bomb in shifting the battlefronts of wars to proxy wars in developing nations under hegemonic control is as clear and as accepted by historians as we can expect.
It may not be quite on par with the "theory" of evolution being all-but-proven fact, but it's in that ballpark.