As for RSI, there are lots of anecdotes about how to prevent and treat it. I don't think there's anything definitive. I have a large collection of notes: http://thespanishsite.com/public_html/org/ergo/rsi.html
The Fn key is out of the way, making using things like the play/pause controls difficult (I never use them). The escape key is also difficult to hit. And, as expected, I've never used the Paste/Cut/Copy/Undo keys.
It's doubly annoying because the keyboard is almost all that I want, so these obvious, pointless defects are all the more hurtful. I'm not sure it actually wins against a Sculpt.
So far I never had any problems this way but every time I try to work with my fingers on the home row, my wrist and arms immediately tell me to stop. I'm not as fast as a professional typist, but couldn't care less about mere speed as long as I'm comfortable.