As someone who has spent a good chunk of their career building high performance networks and another chunk of it working closely with developers who care a lot about those networks, I'm constantly amazed at how little top tier graduates from well respected schools know about networks.
Relatively basic stuff, like what does your application's traffic look like on the wire, how an OS determines what to do with a packet, how latency affects applications, and many other things are completely foreign to way too many developers. I could go on and on, but given the connected nature of things today, it seems like a very overlooked area.