Do you think using psychedelics might be a reasonable substitution for meditation? Not that it is guaranteed, but that under the right circumstances with the right person it could achieve the same results.
No. Psychedelics can be a useful way to get some of the insight that meditation can also provide, but meditation practice over a sustained period changes the brain, so that more positive states of mind are available all (or at least more of) the time.
Does it physically change it, or does it kind of rewire the way you think?