The problem with groundbreaking work is often that any handful of experts can tell you that it's nonsense. E.g., look at the reception that Barry Marshall got when he proposed that stomach ulcers were caused by bacterial infection. [1] All the experts "knew" it was caused by "stress, spicy foods, and too much acid" in the stomach. Eventually he got the Nobel prize, but you have to wonder what else we're missing out because whoever discovered it wasn't as dogged or as lucky as Marshall.
[1] http://www.achievement.org/autodoc/printmember/mar1int-1