My enjoyment of the web improved immensely when I disabled font selection on web pages and imposed my own serif font over them all.
Occasionally this does result in breakages when a particular site relies on icons embedded in a web font but I accept that as the cost of my choice.
I was once complaining to a friend how ugly site X is and he said it looked right to him; later when I saw his machine it has a nice display that made site X look twice as better on my shitty display.
Lots of sites are designed on (and for?) high density displays and it ends up looking awful on low resolution screens like mine.
Also most 'normal' users will never pay the x4-x10 premium price for some fancy IPS display and calibrate its colors.