I also find myself often having to do trial and error stuff to fix my code (also while in a paused state in the console). I mean it's pretty nice that you can actually do this, don't get me wrong. But overall, I am slower and less productive with immutablejs than I am with vanilla JS / JSON objects.
It's a trade off people really should keep in mind before pulling the trigger on immutable data structures. Sure, you get that performance boost, but do you actually need it? Are your React views really so slow (or are you running on slow embedded hardware like I am)? Or are you just drinking the kool aid because immutable data is hot right now?
You get runtime perf improvements in certain cases, at the cost of opaqueness, productivity and complexity. Make sure it is worth it.