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Comment by KirinDave | Hacker News Reader

All I can say is, you do not know what the Placebo effect is. You don't understand why you cannot use it as a therapeutic invention. You do not understand why most drugs benefit from the placebo effect already.

Please, pleasepleaseplease go and read up on what it actually is.

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Woah there tiger-- where do you get that I am suggesting using the placebo as a therapeutic invention!? (If it makes any difference, I meant to type "due to" rather than "do to"). I am suggesting that the following situation might exist:

1) Drug A is 5% effective

2) Placebo is 10% effective

3) No one ever gets the benefits of drug A, since its benefits are masked during trial.

A placebo gets used to determine the margin of error for a particular test. The drug being tested must show significant improvements over the placebo's measurements in order to prove that it is effective.

If your theoretical Drug A performs worse than the placebo, then the effectiveness that it had should be considered to be within the margin of error, and therefore not better than taking nothing at all.

Well... But since placebos can't be used therapeutically, and Drug A can, doesn't that make it better than nothing?

If the drug can't outperform the placebo, then it doesn't make it better than nothing because you're adding chemistry to your body without any assurance that it's going to actually do anything.

But "the placebo" is not a static thing. If we designed experiments differently, the placebo effect might be able to be reduced (say to 3%), in which case drug A would now beat it.

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