http://www.ibtimes.com/pulse/nobel-prize-2015-betting-odds-w...
Something similar to the DraftKings affair maybe, where someone or several someones with insider information are using it for their advantage?
She wasn't a dark horse to win though, she's been favored for at least a year now:
http://www.newyorker.com/culture/cultural-comment/nonfiction...
So it might be a case of a Prediction Game doing right
I remember from some years ago the Hollywood Stock Exchange ( www.hsx.com/ ), an online game where people "invested" on movies, was used as a "crowd wisdom" source for decisions on whether to fund movies, etc, and was fairly accurate IIRC.
Maybe there's a similar opportunity for other fields? A Startup Stock Exchange game? :)