Zigging from clem's zag, let me put this another way. There absolutely, positively, beyond a shadow of a doubt will be major political issues that arise from off-planet habitation.

But, to be honest, not particularly all that more major than any number of issues that arise on Earth all the time, and we generally muddle through them. It'll be a long time before anyone would have any reason to start a shooting war over an off-planet resource.

And science fiction has been predicting the near inevitability that eventually the off-planet colony will demand independence anyhow, a position I see no reason to modify or disagree with, personally. The structural forces in favor of that outcome are just overwhelming.