Sure, which is why I suggested this only for the mid-to-large "classes". I have flown several myself, all the way from the CX-10 (< 12g), to a custom 800 size (> 3kg range). The high end of that could handle an extra 100g without much fuss. The high end of that is also what the airlines are most worried about.
Granted there is some grey area in the 300-500 size copters, where they are large enough to possibly cause some minor damage to an aircraft, but small enough that the weight of an additional TX would pose an issue.
The registration being proposed by the DOT/FAA isn't going to help with these either; they are quite simply too small for any "tail numbers" to be visible at any distance that matters.