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How so?

what do you mean?

I imagine single founders are more likely to click a topic entitled "are you a single founder"

that's true. Maybe it just needs to be re-worded "poll: single founder, or >1 co-founders ?"

On the other hand, each single-founder company results in 1 vote for "yes", while each 2-founder company results in TWICE AS MANY votes for "no"...

Only if all the founders browse HN.

Also, people not running a startup at all could answer "no".

I don't think so. More likely the investor driven cult of must-have-multiple-founders has distorted people's perception.