Shit I've seen: silent memory corruption, silently dropping the last element of an array if and only if it is the last declared field in the structure, killing the debugger every time you hit the bridge, inaccessibility of critical code because it uses X unsupported language feature, event-loop integration nightmares (IO suppression / null-routing / deadlock), exception incompatibility, unconfigurable signal/interrupt stealing. And that's all without counting the "usual suspects" of documentation, performance, and testing issues.

Maybe the Julia-Python bridge doesn't have any of these problems. But I'm not going to be the one to find out.