I just wish that there was one unambiguous spec that they all supported. How many man-hours on aggregate have been wasted tweaking CSS and futzing with javascript to try to achieve identical results across browsers that have all these slight and not-so-slight differences of opinion about the HTML, CSS and ECMAScript specs?
A whole other world of pain is when you get into browsers that are embedded in GUI frameworks, or as extension points in other products. You really have no idea what they support, until you try something and see it is broken. Does this browserPanel object use the system version of IE, or some other version, or an old, forked version of WebKit, or some other Lovecraftian monstrosity?