For example I remember doing a Mandelbrot set generator in js about 3 years ago and it was a lot slower than C#. I'm talking orders of magnitude, methods that took 10 ms in C# would take 1000 ms in js.
But worse than that it hit incredible performance problems when I had an array of more than 10,000 items and tried to use push/unshift or a shift/pop.
I'm no language expert, and I never really dug into why as it was just for fun. Be interested to hear other people's perspective or a more technical explanation. I'm not really interested in those 'we tested these simple method speed' comparisions, I'm more interested in practical experiences.
EDIT: Regarding tooling, I'm presently optimizing js in a client's site and the profiling in dev tools is still basic compared to professional tools in C# for example, so this guy needs to expand his experience if he thinks DevTools is 'good'.