I used it for a couple months at the oral dose that the early phase NIH clinical trial found to be effective. I did feel like i got a positive benefit from it with no side effects, though didn't do any extensive blind testing myself so it's purely anecdotal. I found it to lift some constant anxieties a bit, and help guide my overall outlook on life more positively.

That said, I did find ketamine to be an extremely effective anti depressant with the primary effects being immediately noticeable and positive. I currently re-dose on ketamine every couple months and take bupropion daily--between all of these I've been able to greatly reduce fairly severe depression that went untreated and worsened over a 10+ yr period.