If a programmer writes "X+1 > X", chances are this is an overflow check. Doing this is perfectly defined by the standard if X is an unsigned integer, but not if it's signed. That's what doesn't make sense, since they could've made the unsigned case undefined as well.
which allows a broad range of loop optimizations to kick in
What sort of optimisations exactly, and just how significant are they? I don't believe C should be a language where the compiler does all sorts of high-level optimisation; it should be a straightforward "do what I say" type of language where you get almost exactly what you write, and the only optimisations should be at the level of things like instruction selection --- the optimisations that a programmer would not be able to do at the source level.