Prominent examples:
1. Lower-middle class Southern whites in the U.S. (with whom Twain was intimately familiar) embrace right-wing rhetoric (devout opposition to a godless, liberal govt that rewards a free-loading underclass) while the Republican Party caves to the self-interest of the mega-corp oligarchy. These folks who would benefit from social reforms reject all such liberal notions because, well, they still believe anyone who's not white and Christian is out to take away what little they have. But regressive conservative tax policy is actually doing them harm. (tl;dr: see the success of Fox News, with its overwhelmingly white/old audience. http://www.forbes.com/sites/greatspeculations/2015/04/02/rat...)
2. Given the above in the U.S., is it any wonder radical Islam succeeds in less affluent, less educated areas of the world--where there's very little exposure to outside ideas. And there's certainly very little opportunity for social/intellectual/economic mobility.