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Anecdotal: I experienced this doing stronglifts 5x5, which is a program that systematically keeps you lifting near your 5 rep max. Squats in particular seem to mess up my CNS. Moderate weight lifting is awesome for my mood and cognition, heavy weightlifting is destabilizing.

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Did you end up changing your routine or did you stick to it? I started stronglifts 5x5 a few months ago and the weights are heavy enough now that I'm failing sets in most exercises each session. It's hard to get the motivation to keep going.

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