Treatment of major depressive disorder using botulinum toxin A

Treatment of major depressive disorder using botulinum toxin A: a 24-week randomized, double-blind, placebo-controlled study.

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What I find interesting is, that this seems to be almost a magic bullet for some depression. Half of the patient group had it's HRSD* score halved after measly 2 applications. Halved means depression gone (0-7 is OK, 7-20 is depressed). It seems that disrupting the feedback cycle between facial muscles and mood can be quite powerful.

First study on this was published in 2006.

http://www.psmag.com/health-and-behavior/can-botox-cure-your...

Yet there is very little research on this (4-5 studies) - even though such research is really comparatively cheap. All that is needed is a researcher who can evaluate the subjects and some very short sessions to administer the injections.

Meanwhile, millions of people are continually being prescribed psychoactive drugs with unpleasant common side effects, such as nausea, dry mouth, inability to have an orgasm, weight gain, erectile dysfunction, etc.

*https://en.wikipedia.org/wiki/Hamilton_Rating_Scale_for_Depr...