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I am really interested to know if this allele (C4A) has been under selection or not. The fact that it is in the middle of locus of immunological genes could mean it has just been carried along with the actual selection being for immune function against infectious disease.

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It wouldn't be the first mental illness possibly caused by an overactive immune system

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919277/

Well a lot of mental illness associates with "promiscuousness" (hate that moralistix word) so there is an easy argument for heritability especially for onset at peak fertility

Historically being promiscuous was associated with a low effective fertility. The reason why is if you are a peasant the resources required to raise a child to adulthood need both a mother and a father. The children of single mothers just starved to death.

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