Mind uploading.
It's definitely far off. But it seems to me this could be an amazing shortcut/hack to achieve a lot of other things here: once we have mind uploading, we've basically conquered death. We can also probably figure out, at that stage, how to run the minds faster or with extra memory or something, increasing the standard human intelligence.
This is also a way to achieve "superintelligence" via human-based intelligence, rather than through artificial intelligence.
That would be where I'd bet my money.