I don't like QWERTY for a number of reasons, but feel forced to use it out of respect to my peers at work. I succeeded at learning a better alternative, Colemak, at home, since it is not far from QWERTY. But you don't need to change your whole layout - you can do incremental stuff to improve your situation.

For example, I found it silly that () [] {} and /\, symbols that I use so very often every day, are placed so far away from home row in both Colemak. Also, I was annoyed with the Alt key being placed really awkwardly on my MacBook Pro. And here CapsLock was going totally unused... So I changed CapsLock to Alt, Alt+j to (, Alt+k to ), Alt+Shift+j to [, Alt+Shift+k to ], Alt+l to {, Alt+æ (the key just right of l on my Danish QWERTY keyboard) to }, Alt+u to / and Alt+i to \. It was something like that - I can't check since the computer is broken at the moment. And it was glorious. You should try it out - just change the stuff that bugs you the most to begin with.

I used a program called Ukelele for Mac to change my keys. Unfortunately, it's a bit harder to remap CapsLock in Windows, which is what my workstation uses.