I thought that Reddit has originally solved the problem of tuning each user's front page to their own tastes. Have I misremembered?
click on https://www.reddit.com/subreddits/
then open the console in your browser and type this :
setInterval("$('a.option.active.remove.login-required').first().click()",400)
I didn't find the option to remove all default subscriptions at once in the settings, it might exist though. setInterval is needed because for some reasons ajax communication is throttled by reddit.