A lot of the Adobe Stuff including the Macromedia divisions when they were alive are still immediately next door or across the street. I think their use of 650 Townsend was mostly for overflow office space.
The merry-go-round was given to us by Apple:
http://radio-weblogs.com/0106797/picts/MacromediaFlashOffice...
If you ignore the homeless problem (which is actually in busy areas like Tenderloin), there are no real "sketchy" areas in SF. You have to cross the bay for that.
If you ignore the crime problem in crime-heavy areas, you might say that those areas have no crime problem. It doesn't mean that you're right.
EDIT: Looks like the city is going to try to clean it up: http://sfist.com/2016/02/23/division_street_tent_city_to_be_...
It is a mall.