Salary difference. On average Most decent experienced devs in London make around 50-60k pounds which is around 80-85k dollars. An entry level dev in SF makes anywhere between 90 - 120k dollars and most experienced devs earn at least 120k dollars with the range around 110-150k. So roughly a 30-60k+ dollar/year difference.
Healthcare. Almost all the companies I've worked for have covered my healthcare costs so I only have to pay copays - as an idea 20 dollars to see my GP and 30 to see a specialist. I had 8 weeks of physio last year and my total out of pocket was around 600 dollars including a CT scan, which I could pay using pre tax dollars. So the overall cost was pretty low. I also got to see a physio the same day rather than waiting 6 weeks+ on the NHS. My total max out of pocket is 3000 meaning I don't pay anything more than that. Given the significantly higher salary even if I were to hit my max it would still be worth it.
The cost of living is comparable although certain things are cheaper - gas, trainers(sneakers), car insurance to name a few. Food is roughly the same I reckon.
Overall working in London vs working in the US I saved significantly more money - it's not even close. Although a tin of heinz beans costs two dollars so that's made a pretty big dent in my savings ;-)