I do. A few years ago I put together a presentation on how to use it effectively for personal finance: https://docs.google.com/presentation/d/1CUSct3YGvpVdKI_D_jCI...

The long and short of it is that GNUCash rests upon an ancient bed of Scheme and C, and so isn't quite ready for the cloudz.

I use it primarily because quicken on mac is completely useless when you have multiple accounts with different currencies. They even list your totals wrong like "100 USD + 100 GBP = 200 EUR" last time I tried it. And there aren't that many alternatives for personal use since i don't need anything extremely complex.

GNUcash is probably the ugliest piece of software that I use regularly, but at least it works. Depending on one's needs YNAB or Quicken might be a better choice though - but neither work well with multiple currencies or even accounts.