I can't think of a language where you would always want to canonicalize strings at a global scope. For example, consider the case where you have a large number of threads and cores. Unless the strings are explicitly allocated on their own cache lines, any thread that references a string now has to worry about false sharing. You would also need to worry about the contention on the canonical store.
At a user level, in languages like Java, there's generally no reason to create any intermediate string if you're already reading from a direct byte buffer. This covers a fairly large set of use cases. There may be other techniques considering Java supports scalar interpolation now, but direct byte buffers have been the most effective in my experience.