Maybe it's a pattern I've seen: people don't move to San Diego for a career, they move for the lifestyle. Now I know there are a ton of bio-tech companies and, yes, Qualcomm. But the cost-of-living is still high and San Diego companies are notoriously stingy on salary (Sunshine Tax). Beside bio-tech, what are the other dominant industries in San Diego? Some idea: military, tourism, retail, etc. San Diego is awesome, but the tech opportunities don't match the size of the city (8th largest in the US!).