When the Adobe leak hit, I was already using Keepass to generate random passwords for each service I use.

So, I changed the password on the Adobe account. I've never had an adverse event based on that leak.

Lots of people know your email address. It's your job to make your email address useless, combined with a data breach, to guess a valuable password. If you use passwords like "mysecret-hackernews", "mysecret-github", and "mysecret-paypal" then you're in serious jeopardy if your "mysecret-adobe" gets out. But if you use a bunch of random gibberish for each password, you're relatively safe, at least from that particular attack.