Hand-held calculators might have been carried on many NASA missions, but not the early ones. The first missions started in 1961 and hand-held HP calculators weren't invented until more than ten years later. By that time we had already been to the moon 6 or 7 times.

The first actual hand-held calculator I every saw was a Bowman Brain (simple 4 function calculator) it was for sale in 1971 at the MIT COOP (the bookstore). I only knew one person that bought one; the rest of us continued carrying around our slide rules (they came in handy leather holsters with belt loops.) The HP that came out about a year later was a real scientific calculator.

Years before that, sometime between 1965 and 1968, on an episode of Lost in Space (a TV program with a family of early space explorers lost in outer space) the son, Will Robinson, was carrying around a large device about 3 inches thick and a foot tall that looked like a calculator. I thought the idea quite marvelous and went to bed thinking about it and how much better it would be than my slide rule for playing around with calculations. (I was a weird kid.)