I still think that in IBM's case this depends on what you mean by mainframe. Midrange systems (ie. AS/400) are power boxes and today even sold as such (IBM will sell you the hardware as "IBM Power system" with choice of AIX, OS/400 or Linux as OS). On the other hand I'm almost certain that System z CPUs are microcoded monstrosities that run z/Architecture machine code pretty much natively.