Peter Thiel: An Angel on a Hot Streak
businessweek.com
businessweek.com
Edit: Actually, this makes sense considering his business acumen. He's shooting for most lives saved per dollar. The chance of success of these organizations is lower than typical charities, but the expected benefit is immense compared to typical charities. For example, let's say the Methuselah foundation has a 1% chance of finding a cure for aging. 7,000,000,000 * 0.01 = 70,000,000 expected lives saved.
You beat me to it, but I'm leaving this comment to encourage people who aren't familiar with these organizations to look them up.
I agree and this bothers me a lot. Startups are easier to start and we're making silly twitter apps or trying to sell out for 5 million. Very few companies strive to build a lasting legacy.