I was going to blog about it tomorrow (never ruin a good chance to blog)
Basically for some reason F# barfs on large types, say types with 500 fields in them. I think the breaking point is 300 or so. There's also another bug that I'll save for the blog entry.
Microsoft was responsive as hell -- I had an email response within minutes and the engineer and I were emailing back and forth all afternoon. I was very impressed. The F# dev guys rock, even though I'm not happy at all with having a broken app.