Also consider living a bit further away (Santa Clara or even San Jose). Traffic sucks but it is a necessary evil. You might be able to get a decent 2 bedroom for 2500. Make sure your wife has immigration status that allows working else you will be screwed. I have many friends who had highly educated spouses who ended up sitting at home for a year+.
Edit .. some more additions. I don't want to scare you but want to give you some data.
1) Make sure you budget for a car. While uber is awesome, it is very hard to live here without a car. Everything is sprawled out. A cheap car isn't great value ... you end up spending 20K on a car (you recover costs when you sell it of course).
2) Make sure the uni covers health insurance for your whole family ... it is often a payroll deduction so find out how much they charge.
3) East Palo Alto is dangerous so don't go there.
4) I eat out all the time ... food is not as expensive compared to Europe. With a kid, eating out probably isn't a good idea though. Consider shopping in bulk at Costco (need a car for that though).
5) I see posts on craigslist about professional couples who want to share a house. I hope you get lucky and find one of those situations. Seems like a good option.
6) Find out if the uni has subsidized housing. UCSF does and offers it to post-docs. That can be an amazing deal.
Best of luck to you.