So in looking at the Kangax tables when the next Safari comes out, it looks like all major desktop browsers will have support of the big ticket ES6 features (arrow functions, destructuring, default params, Map/Set/WeakMap, Proxies). Unless you're doing JSX, type annotations, or upcoming stuff (async/await, decorators, object spread, class properties) you can drop transpiling from your dev workflow and only do it for prod.