Your body is not a bomb calorimeter. If you're looking to thermodynamics to explain weight loss or gain you'll be disappointed.
Sure, if you're tracking your food intake closely, maintaining a significant deficit, and not losing weight, talk to a doctor about your thyroid. If you're putting in hours in the gym and eating a lot and not gaining any muscle, talk to your doctor about your testosterone level. But if you're looking to hormones and whatnot first, you're probably just deluding yourself.