What I believe, and what I think others have also concluded, is that it shouldn't be fatal. That is, when the dust has settled and you trim down usage and have a decent maintenance outage, you should be able to defrag the filesystem and get back to normal.
That's not possible with ZFS because there is no defrag utility ... and I have had it explained to me in other HN threads (although not convincingly) that it might not be possible to build a proper defrag utility.