"If the antibodies already exist within your organization to destroy new endeavors, you need to go outside of the organization to overcome them."
Another option is to just fire or move employees that are resistant to change and innovation to other parts of the company where their resistance to change might be more helpful. I don't understand why this option is not considered or discussed.
Many organisations sometimes have costly problems, and try to learn from them by adding new procedures to stop the problems recurring. After a few years, an accumulation of such procedures can raise the costs of a new project significantly - even though every rule is a reasonable one put in place with the best of intentions.
For example, where a startup can test a concept with a PHP website on a single server using MySQL, a large company might have standards calling for a high availability configuration, a 24/7 support rota, monitoring logging testing automatic scalability change management backups and security to these standards/levels and independently audited, a bug bounty program...
Before you know it a project a startup could have prototyped with one guy and a week needs several guys and several months - but the reasons for it are all individually reasonable and firing the people behind them makes no sense at all.