Most things can be toxic in high doses. Yes, being natural doesn't say much but I wasn't trying to relate that it's healthy for you just because it's natural.
[1] http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrs...
Honestly, other than fear of 'teh chemicals,' I can't think of a reason.
You are making the false assumption "natural" foods are a correlated group as far as health goes. This is empirically false (ignoring the fact that natural has no scientific definition to begin with). Studying sucrose won't inform you of the dangers of cyanide though both are "natural".
The exception is if we can prove the two operate under the same fundamental mechanisms within the body. But there's nothing different about natural growing plants and man made substances under this sort of research. A molecule is a molecule.