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Nix supports CMake fine. In my experience adding new packages is not too hard as long as they're not GnuCash 2.6 ;)

Any change will lead to a new output folder, there is no option of reusing them.

Why not just give it a try in VirtualBox to see for yourself how far along it is?

I guess I understand why it has to make a new folder - it just seems that that would means you have to redirect (and relink) anything that uses a recompiled library. Okay, I'll definitely start to dive into this. I was asking around to see if it fits my workflow. thanks!

Yes, that's exactly true. There are some workarounds, but they're a bit hacky and don't normally get used...

Luckily there's a NixOS build cluster, so you don't normally need to recompile glibc yourself. :)

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