It's no surprise then that these "losers" are seeking something better for themselves. They may not know what the right answer is, but no one does. And the argument that "we should keep trying the same thing" eventually falls flat with no results. So a headlong leap into the unknown looks better than pounding your head against the same wall over and over again.
Which means this boils down to a very obvious realization: people who don't see the benefits of the status quo don't like the status quo. To those for whom the status quo is working, this comes as a shock. And for whatever reason, this year is the one where that minority becomes a majority.
What I've found shocking in all this is the vitrol of the "winners". Brexiters (and Trump voters) have been called naive, idiots, racists, xenophobes, sheeple, and worse. ("Losers" comes to mind.)
No matter what happens as a result of the UK/EU decision, the U.S. presidential election, or other policy changes around the world, we have to figure out how to fix the problem at the core of all this. Why so many people are unhappy. And name-calling isn't going to help.