Sharing CPU resources between user space drivers is certainly a challenge. The best way to view this is that the kernel provides a general purpose solution for sharing resources with some associated overhead. Tools like DPDK and SPDK let you opt out of that, but now you are responsible for intelligently sharing the hardware.

You, as the application developer, have a distinct advantage though - you only need to solve the problem for your application, and using that knowledge can often lead to more efficient solutions. This may mean dedicating cores to the network or disk, or it may mean working in fixed sized batches, etc.