At hundreds of miles an hour, isn't wind resistance orders of magnitude stronger than rolling friction? If you live somewhere with even moderate wind, and that wind doesn't always blow in the same direction, you'd want to take off with the wind and land against it, which would cause problems when that meant landing on the downslope or taking off on the upslope. I suppose you could mitigate that by having runways that slope up and to the east, down and to the east, etc.