Pretty much every professional job I've had used polyglot programming of some sort - when I was in financial software it was mixed Java/C/Fortran numerics, when I founded my first startup it was polyglot Javascript/ActionScript, and at Google it was a large server that was first Python/C++ and then Java/C++. The boundary between languages is always problematic. And the reason for that is because you choose memory layout to make certain trade-offs around the access patterns for that data. Do you inline data structures in a vector, or chase pointers? Do objects carry their type information with them so you can manipulate them dynamically, or do they throw it away at compile-time for greater efficiency? Do you get O(1) string indexing or native UTF-8? Do you allocate on the stack or the heap? Do you copy, borrow, move, or COW?
And then when you go to switch representations to call into another language, you pay a cost to convert all the data structures you might be touching. In many cases, that cost could be more than you saved by using optimized representations in the first place.