While Chrome's proposal to white-list the top-10 domains is a good start at curbing the loading of Flash on my laptop, I prefer the approach being considered by Safari to report that Flash (and other legacy plugins) is not available on the platform even if it is installed. [2]
Safari's approach will ensure that most users see HTML5 content and won't really miss Flash. Folks who use sites like Twitch that insist on Flash will know how to force Safari to load the content they want to view.
Unfortunately, Safari's user share outside of Mobile is very low. We need Chrome, Firefox and IE to adopt a similar approach (or agree on an approach for all vendors) if we are to really rid ourselves of Flash.
1. https://bugzilla.mozilla.org/describecomponents.cgi?product=...
2. https://webkit.org/blog/6589/next-steps-for-legacy-plug-ins/
Edit: Moved links to the end of the post.