At Facebook, we had clients talk http2 to edge nodes near the users, which then edge terminated TLS and opened up the request to figure out which upstream was best to forward the request to. We kept http2 conn pools to each upstream from a given edge location. We also had tunable amounts of domain sharding so that the client could open N http2 conns at once to a given edge hostname (cdn[1-4].facebook.com vs just api.facebook.com or www.facebook.com). This helped with head of line blocking, assuming that your ISP wasn't hopelessly over-congested. In that case, no amount of sharding will help you, and sometimes it even works against you depending on what tcp middleware your mobile ISP is using.
We did different TCP settings for edge<->origin conns than edge<->user which let us balance between latency and throughput for origin traffic as needed, and we did some interesting work tuning edge tcp settings differently for different user networks too. Things like determining the best congestion window for a given ISP's users, how large to set the send buffers, etc.
Admittedly, this work was much easier since we had good http and tcp instrumentation, and we had high quality links between edge and origin. I just wanted people reading your comment to understand the tradeoffs. We saw a measurable difference in perf with a full http2 stack that made up for the extra complexity of running http2 top to bottom.